![]() ![]() ![]() ![]() In the static case the method clearly showed the difference between needles that were empty, full, or contained a mix of gas and liquid. This property has here been used to visualize the distribution of a drug product in a syringe needle of a drug injection device. Neutron imaging is a nondestructive method based on radiography using neutrons and is suitable for detecting small amounts of aqueous liquids even in metallic casing/sheath/tubing. After filtering it is possible to detect relevant edges and extract motion curves from the spatio-temporal data. Spatio-temporal data sets of the injection process were acquired using remotely triggered injection devices and a camera allowing sub-second frame rates.The motion analysis required the application of an edge-preserving spatio-temporal denoising filter to improve the signal-to-noise ratio. Switching to high temporal resolution we demonstrate that it is possible to follow the injection process. Using high spatial resolution it is possible to resolve the thin films of drug product in foam and even to detect the drug residues in the injection needle. The investigation has two parts optimized for high spatial and high temporal resolution, respectively. Using neutrons it is possible to show small amounts of liquid in capillaries, and foam bubbles are shown with great contrast compared to metal and glass. In this work we are using neutron radiography to observe drug distribution in drug injection devices during the injection process and as post-injection examination. Radiography is a method that has the advantage that it is possible to see through the sample. Nondestructive testing is a common method for root cause investigations of malfunction of mechanical devices, for example, medical devices for drug dose delivery. ![]()
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